Rescuers in the northwest Italian city of Genoa are searching into the night for possible survivors after the dramatic collapse of a motorway bridge.
Police say at least 26 people were killed and 15 badly hurt, when dozens of vehicles fell 45m (148ft).
Reports say cries can be heard from people trapped in the debris. Twelve people are said to be missing.
Some 300 firefighters from across Italy have been using sniffer dogs and climbing gear in the search.
Hundreds of people were evacuated amid fears other parts of the bridge might fall.
The cause of the disaster, which occurred during torrential rain, was not immediately clear but questions had been raised about the safety of the structure.
Interior Minister Matteo Salvini has vowed to bring anyone responsible for the collapse to book.
The Morandi Bridge, built in the 1960s, stands on the A10 toll motorway, an important conduit for goods traffic from local ports, which also serves the Italian Riviera and southern coast of France.
What is the challenge facing rescuers?
« We are continuing with the rescue operations because we think there are other people alive under the rubble, » Genoa police spokesperson Alessandra Bucci told Reuters news agency.
Rescuers from all across northern Italy were at work on the debris.
The Italian fire service tweeted a video of one person being extracted and carefully lowered on cables from a shattered vehicle, which was suspended in the wreckage of the bridge, high above the ground.
Between 30 and 35 cars and three heavy vehicles were on the bridge at the time of the collapse.
A huge tower and sections of the bridge collapsed on to railway lines, a river and a warehouse. Reports suggest that nobody was killed on the ground, although some people were injured.
Marcello de Angelis, who is co-ordinating the Italian Red Cross rescue effort, told the BBC that rescuers were treating the disaster like an earthquake.
« There might be the possibility of some niches being created by the rubble itself, with people being protected by the rubble, » he said.
« The units that we have sent are the units that we use during earthquakes. So it is the same sort of situation – and also the risk of other collapses, obviously, is the same. »
How did the bridge collapse?
A section measuring about 200 metres fell at around 11:30 local time (09:30 GMT). Police say there was a violent cloudburst at the time.
An unnamed witness quoted by Italy’s Ansa news agency said: « We heard an incredible roar and first we thought it was thunder very close by.
« We live about 5km [three miles] from the bridge but we heard a crazy bang… We were very scared… Traffic went completely haywire and the city was paralysed. »
The collapse of the bridge was an « incident of vast proportions on a vital arterial road, not just for Genoa, but for the whole country », said the governor of Liguria region, Giovanni Toti.
« The Morandi bridge connects three major ports in our country, used by tens, even hundreds of thousands of people. They depart from these ports on holiday. These docks receive most of our country’s imported goods. It damages the very structure of the Italian logistics system. We are expecting a very fast response from the government. »
Mr Borrelli said the authorities were trying to arrange help for those affected by the disaster, as well as setting up diversions for traffic.
Is Italian infrastructure underfunded?
The new government has pledged to increase public investment.
The country spent more than €14bn (£12.5bn; $16bn) on its roads in 2006 but that had dropped to less than €4bn after the 2008 financial crisis, after the according to data from the Organisation for Economic Co-operation and Development.
The figures cover spending on new transport construction and the improvement of the existing networks.
Spending started to increase in 2013, when total spend was less than Spain, Germany, France and the UK.
How has the world reacted?
French President Emmanuel Macron tweeted a message of sympathy to the people of Italy, writing in both Italian and French. He said France was ready to offer any necessary aid.
European Commission chief Jean-Claude Juncker voiced his « deepest sympathy and sincere condolences to the families and friends of those who have died, and to the Italian people ».
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